Cellular-Aging and Longevity Pathway Studies

a-Klotho MAB (Monoclonal Antibody targeting α-Klotho pathways) is utilized in pre-clinical and in-vitro systems to investigate mechanisms of cellular aging, oxidative stress regulation, and longevity signaling. It supports research into Klotho-mediated pathways associated with lifespan extension and cellular resilience.

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Renal-Function and Electrolyte-Homeostasis Research

α-Klotho is highly expressed in renal tissue and plays a central role in phosphate and calcium regulation. a-Klotho MAB is used in kidney models to study mineral metabolism, renal protection, and electrolyte balance under physiological and stress conditions.

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Neuroprotection and Cognitive-Function Models

Pre-clinical studies associate Klotho signaling with enhanced synaptic function and neuroprotection. a-Klotho MAB enables investigation of neuronal resilience, cognitive performance pathways, and mechanisms involved in neurodegenerative research models.

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Oxidative-Stress and Anti-Inflammatory Research

a-Klotho MAB is studied for its role in modulating oxidative stress pathways and inflammatory signaling. It is used in cellular models to evaluate protection against ROS damage and inflammatory cytokine activity.

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Cardiovascular and Vascular-Health Studies

Klotho-related pathways have been linked to vascular elasticity and endothelial function. a-Klotho MAB supports research into arterial health, calcification processes, and cardiovascular aging mechanisms.

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Bone-Metabolism and Mineralization Research

α-Klotho interacts with FGF23 signaling to regulate phosphate metabolism and bone homeostasis. This monoclonal antibody is used in skeletal models to study osteogenesis, bone turnover, and mineral balance.

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Metabolic-Regulation and Insulin-Sensitivity Studies

Emerging research suggests Klotho involvement in glucose metabolism and insulin signaling pathways. a-Klotho MAB is used to explore metabolic efficiency, insulin sensitivity, and energy homeostasis in experimental systems.

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Signal-Pathway and Receptor-Interaction Studies

a-Klotho MAB allows targeted investigation of Klotho-FGF receptor interactions and downstream signaling cascades, making it valuable for pathway-mapping and receptor-binding studies.

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Pharmacokinetic and Stability Research

As a monoclonal antibody, a-Klotho MAB demonstrates extended stability and specificity in controlled environments, supporting long-duration studies of protein interaction, receptor modulation, and signal persistence.

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PRODUCT DETAILS

Application: Research monoclonal antibody targeting α-Klotho pathways
Appearance: Lyophilized or liquid solution (clear to slightly opalescent) in sterile glass vial
Chemical Class: Monoclonal antibody (IgG subtype, lab-specific)
Molecular Weight: ~150,000 g/mol (typical for IgG antibodies)
Target: α-Klotho protein
Purity: ≥98% (analytical grade)

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STORAGE

Lyophilized material is stable under controlled conditions.
Store at 2–8°C. Do not freeze repeatedly.
Protect from light and agitation.
After reconstitution, store refrigerated and use within recommended study timeframe.

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RESEARCH DISCLAIMER

Research Use Only (RUO). Not for human or animal use. Not for diagnostic, therapeutic, or clinical applications.
No claims are made regarding anti-aging, cognitive enhancement, or metabolic effects in humans.
End-user assumes full responsibility for determining suitability within their research protocols.