Literature-Based Summary (Non-Clinical Context)

Melanocortin Receptor and Pigmentation Research

Melanotan I (MT-1), also known as Afamelanotide, is a synthetic linear analog of α-melanocyte-stimulating hormone (α-MSH). In laboratory research it is studied for its high affinity toward the melanocortin-1 receptor (MC1R), a receptor expressed in melanocytes that regulates melanin production and pigment distribution.

Melanin Production and UV-Response Models

In cellular models, Melanotan I has been observed to stimulate eumelanin synthesis and promote melanocyte activation. These findings support its use in experimental research examining photoprotective responses, melanin-biosynthesis pathways, and skin-cell adaptation to ultraviolet exposure.

Dermatologic and Photobiology Studies

Melanotan I is frequently utilized in dermatologic research exploring the biological role of melanocortin signaling in skin physiology. Investigations focus on how melanocyte activation may influence UV-response mechanisms, oxidative stress mitigation, and pigment distribution within epidermal cells.

Cellular Pigment Signaling Pathways

Laboratory studies examine Melanotan I as a model compound for understanding MC1R-mediated intracellular signaling, including cyclic-AMP activation pathways and transcriptional regulation associated with melanin synthesis.

Photoprotection and Oxidative Stress Research

Experimental findings suggest increased melanin production may contribute to UV-induced oxidative-stress resistancein skin-cell models. These systems allow researchers to investigate potential mechanisms of melanin-based photoprotection.

Pigmentation-Disorder Research Models

In experimental dermatology settings, Melanotan I has been studied for its ability to stimulate melanocyte activity, supporting research models investigating pigment-distribution disorders and melanocyte-function restoration.

Storage Details

Lyophilized Melanotan I (MT-1) is stable at room temperature for short periods when protected from moisture and light. For optimal long-term stability, it should be stored refrigerated (2-8 °C) in a sealed container. After reconstitution, solutions should be stored refrigerated and used within a limited timeframe according to laboratory protocol.

Chemical Information

Appearance: Solid white lyophilized powder in 3 mL glass ampule
Chemical Formula: C78H111N21O19
PubChem CID: 16129643
CAS Number: 75921-69-6
Molecular Weight: 1646.9 g/mol
Synonyms: Melanotan I, MT-1, Afamelanotide

Storage

Store at ≤25 °C, sealed, protected from heat, light, and moisture.

Concentration

≥98%

Research Use Statement

Research Use Only (RUO). Not for human or animal use. Not for diagnostic, therapeutic, or clinical applications. No claims are made regarding tanning or dermatologic effects in humans. End-user assumes responsibility for determining suitability for specific research protocols.