LL-37 Complex (5mg)

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Existing research has found the following:

  • Supports Antimicrobial Peptide Research – Studied for its broad-spectrum activity against bacterial, viral, and fungal pathogens in experimental models.

  • Explores Immune Modulation Pathways – Investigated for its role in enhancing innate immune response and coordinating host defense mechanisms.

  • Evaluates Wound Healing & Tissue Repair – Examined for promoting epithelial regeneration and accelerating skin and soft tissue recovery.

Description


Antimicrobial and Host-Defense Studies

  • LL-37 Complex is a research-grade blend containing the human cathelicidin peptide LL-37 and complementary immune-modulatory components. In pre-clinical and cellular models, LL-37 and its synergistic cofactors have been shown to display broad-spectrum antimicrobial activity against bacteria, fungi, and enveloped viruses.

Immune-System Modulation

  • In non-clinical experiments, LL-37 and related peptides have been observed to regulate cytokine production, enhance macrophage activation, and balance immune-cell signaling, allowing study of innate and adaptive immune-response pathways.

Wound-Healing and Tissue-Regeneration Models

  • Experimental data demonstrate that LL-37 accelerates re-epithelialization, angiogenesis, and fibroblast migration, supporting its use in research on tissue-repair and wound-healing mechanisms.

Inflammatory and Autoimmune Research

  • Pre-clinical findings indicate that LL-37 can modulate inflammatory cascades by influencing NF-κB and Toll-like receptor pathways, enabling exploration of chronic-inflammation and immune-dysregulation models.

Gastrointestinal and Microbiome Studies

  • In in-vitro assays, LL-37 and its analogs have been studied for their effects on epithelial-barrier integrity, mucosal immunity, and microbial diversity—providing a tool for gastrointestinal and microbiota research.

Respiratory and Pulmonary Models

  • Non-clinical literature supports the use of LL-37 in examining immune and antimicrobial mechanisms within lung tissue, aiding studies of airway defense, infection recovery, and mucosal resilience.

Autoimmunity and Immune-Tolerance Mechanisms

  • LL-37 and its complexed forms have been used to evaluate immune recognition and tolerance signaling in autoimmune-disease models such as rheumatoid arthritis and lupus, helping elucidate peptide-mediated immune-regulation dynamics.

STORAGE DETAILS

Lyophilized LL-37 Complex peptide is stable at room temperature for 90 days; however, it should NOT be stored below freezing for any extended period. After reconstitution, refrigerate at ≤36°F.

Product Specifications

  • Appearance: Solid, white powder in 3mL glass ampule

  • Chemical Formula: C177H293N51O43

  • CAS Number: 219685-50-4

  • Molecular Weight: 4493.23 g/mol

  • Synonyms: LL-37, CAP-18, FALL-39, 219685-50-4

  • Storage: Store at ≤6°C, sealed, away from heat, light, and moisture.

  • Concentration: ≥98%

    Research Use Only (RUO). Not for human or animal use. Not for diagnostic, therapeutic, or clinical applications. No claims are made regarding antimicrobial, immune, or wound-healing benefits in humans. End-user assumes responsibility for determining suitability for specific research protocols.