Antimicrobial Mechanisms and Host-Defense Models

• LL-37, a cationic amphipathic peptide derived from the human cathelicidin gene (CAMP), has been widely studied in pre-clinical and cellular models for its broad-spectrum antimicrobial properties against bacteria, fungi, and enveloped viruses.

Innate-Immunity and Immune-Modulation Research

• In in-vitro and animal studies, LL-37 has been shown to influence immune-cell recruitment, cytokine balance, and Toll-like receptor signaling, supporting investigations into innate-defense and immunomodulatory pathways.

Wound-Healing and Tissue-Repair Studies

• Pre-clinical literature reports that LL-37 promotes keratinocyte migration, angiogenesis, and epithelial regeneration, providing a framework for studying cellular-repair and wound-closure mechanisms.

Inflammatory and Autoimmune-Response Models

• LL-37 has demonstrated context-dependent effects on inflammatory cascades in non-clinical systems, making it a key compound for exploring cytokine regulation and immune-homeostasis research relevant to chronic-inflammation models.

Gastrointestinal-Barrier and Microbiome Research

• Experimental data show that LL-37 may help preserve intestinal-barrier integrity and modulate gut microbial balance, supporting studies into epithelial-defense and mucosal-immunity mechanisms.

Respiratory-Epithelium and Infection Models

• LL-37 has been used in pre-clinical respiratory studies to examine antimicrobial protection and immune modulation within pulmonary tissue, aiding investigation of airway inflammation and infection response.

Autoimmunity and Immune-Tolerance Studies

• Laboratory research suggests LL-37 may influence self-antigen recognition and immune-complex dynamics, enabling further exploration of autoimmune and inflammatory-signaling pathways.

STORAGE DETAILS

Lyophilized LL-37 peptide is stable at room temperature for 90 days; however, it should NOT be stored below freezing for any extended period. After reconstitution, refrigerate at ≤36°F.

Product Specifications

• Appearance: Solid, white powder in 3mL glass ampule

• Chemical Formula: C177H293N51O43

• PubChem CID: (Specify if available)

• CAS Number: 219685-50-4

• Molecular Weight: 4493.23 g/mol

• Synonyms: LL-37, CAP-18, FALL-39, 219685-50-4

• Storage: Store at ≤6°C, sealed, away from heat, light, and moisture.

• Concentration: ≥98%

  Research Use Only (RUO). Not for human or animal use. Not for diagnostic, therapeutic, or clinical applications. No claims are made regarding antimicrobial, wound-healing, or immune-support benefits in humans. End-user assumes responsibility for determining suitability for specific research protocols.