FOX04-DRI (15mg)

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Existing research has investigated the following:

  • Senescent Cell Signaling Models – Studied in pre-clinical systems for its interaction with cellular pathways associated with senescent cell signaling and clearance mechanisms.

  • Cellular Turnover & Metabolic Pathways – Evaluated in experimental models for its role in cellular turnover processes, mitochondrial activity, and intracellular energy regulation.

  • Cellular Stress & Functional Maintenance Pathways – Examined in laboratory settings for its influence on pathways related to cellular stress responses and maintenance of cellular function.

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Description

Senolytic Activity and Mechanistic Targeting

  • FOXO4-DRI (a D-retro-inverso peptide analog) has been studied in cellular and animal models for its capacity to disrupt FOXO4–p53 protein interactions, promoting selective apoptosis of senescent cells while preserving normal, proliferative cell populations.

Tissue Rejuvenation and Regeneration

  • Pre-clinical studies indicate that clearance of senescent cells via FOXO4-DRI administration may support improved tissue architecture, cellular turnover, and regenerative signaling in aging model systems.

Aging and Functional Longevity Research

  • Experimental data from non-clinical investigations associate FOXO4-DRI–mediated senolytic activity with delayed markers of physical decline and enhanced organ function in aged animal models.

Selective Cytoprotection

  • Laboratory findings show that FOXO4-DRI preferentially induces apoptosis in cells expressing senescence-associated β-galactosidase or p16^INK4a while sparing non-senescent control cells, underscoring its selectivity in in-vitro systems.

Recovery and Injury-Response Studies

  • Animal research suggests that reduction of senescent cell burden through FOXO4 pathway modulation may accelerate recovery following tissue injury and enhance regenerative signaling cascades. All results remain model-dependent and have not been validated in clinical contexts.

STORAGE DETAILS:
Lyophilized FOXO4-DRI is stable at room temperature for up to 90 days; however, it should not be stored below freezing for any extended period. After reconstitution, store refrigerated at temperatures not to exceed 36 °F (2 °C).

Application:
Investigated for its senolytic (senescent-cell–clearing) activity and potential to promote healthy aging by selectively inducing apoptosis in damaged or “senescent” cells.

Appearance:
Solid, white lyophilized powder in 3 mL glass ampule.

Molecular Data:

Peptide Chemical Formula CAS Number Approx. Molecular Weight
FOXO4-DRI C203H314N56O60S 1896919-47-5 ~4700 g/mol

Synonyms:
FOXO4 peptide D-retro inverso, FOXO4-p53 interfering peptide.

Storage:
Store sealed at ≤6 °C, away from heat, light, and moisture.

Concentration:
≥98 % peptide purity by HPLC.

Research Use Only (RUO). Not for human or animal use. Not for diagnostic, therapeutic, or clinical applications. No claims are made regarding anti-aging, senolytic, or regenerative effects in humans. End-user assumes responsibility for determining suitability for specific research protocols.

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