ARA-290 (16mg)

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Existing research has found the following:

  • Supports Neuroprotective Research – Studied for its potential to preserve nerve integrity and promote repair in experimental models of neuropathy.

  • Explores Anti-Inflammatory Pathways – Investigated for its ability to modulate cytokine activity and reduce inflammatory signaling.

  • Evaluates Erythropoietin-Mimetic Mechanisms – Examined for EPO-like receptor engagement and tissue-protective effects without stimulating erythropoiesis.

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Description

Neuroprotective and Anti-Inflammatory Activity

  • Peptides within this class have been studied in pre-clinical models for their ability to stabilize mitochondrial membranes, limit oxidative stress, and reduce neuroinflammatory markers in neuronal and glial cell systems.

Models of Neuropathic Pain

  • Experimental research has investigated these compounds for their potential to modulate nociceptive signaling pathways and improve function in animal models of small-fiber neuropathy and peripheral nerve injury.

Non-Erythropoietic Cytoprotection

  • Certain mitochondrial-targeting peptides are designed to replicate the tissue-protective effects associated with erythropoietin (EPO) signaling, while avoiding stimulation of erythropoiesis. This feature allows researchers to isolate tissue-protective mechanisms without confounding hematologic activity.

Vascular and Endothelial Function Studies

  • Pre-clinical and early translational studies suggest that similar analogs may enhance microvascular blood flow, protect endothelial integrity, and modulate nitric oxide bioavailability in non-clinical vascular models.

Diabetes-Related Research Applications

  • In animal systems, these peptides have been explored for their effects on mitochondrial dysfunction, oxidative stress, and microvascular injury associated with diabetic neuropathy and related metabolic disorders. Observations remain model-specific and not validated for clinical use.

STORAGE DETAILS:
Lyophilized ARA-290 is stable at room temperature for up to 90 days; however, it should not be stored below freezing for any extended period. After reconstitution, store refrigerated at temperatures not to exceed 36 °F (2 °C).

Application:
Investigated as a non-erythropoietic erythropoietin (EPO) derivative for its potential to reduce inflammation, protect nerves and tissues, and relieve neuropathic pain in early studies.

Appearance:
Solid, white lyophilized powder in 3 mL glass ampule.

Molecular Data:

Peptide Chemical Formula CAS Number Approx. Molecular Weight
ARA-290 C143H243N47O39 1025624-00-7 ~2879 g/mol

Synonyms:
Cibinetide, ARA 290, non-erythropoietic EPO-mimetic peptide.

Storage:
Store sealed at ≤6 °C, away from heat, light, and moisture.

Concentration:
≥98 % peptide purity by HPLC.

Research Use Only (RUO). Not for human or animal use. Not for diagnostic, therapeutic, or clinical applications. No claims are made regarding nerve protection, pain relief, or vascular improvement. End-user assumes responsibility for determining suitability for specific assay systems.

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